![]() ![]() ![]() ![]() The score for The Founding Of An Army has won him the best music in the Golden Deer Awards. Chen has won several Chinese Academy Award nominations for his music from films such as Li BaoGuo and Da Shanghai. Aside from his compositions, Chen is also a well-known performer and a judge for many nationwide music related competitions. ![]() In addition, he has recorded with many world-class orchestras such as the Asian Philharmonic Orchestra, the China Philharmonic Orchestra and the Budapest Film Symphony Orchestra. He has also collaborated with many famous directors and musicians including Jing Wang, Weiqiang Liu, Weimin Ye, An Dong, Guangrong Chen, etc. It added more variety and cultural influences to his music, which is starting to get more recognition internationally. Over the years, Chen has worked with many artists from different cultural background. During his study, he received professional training in both music production and composition from renowned musicians like An Dong. Chen graduated with honors from the Shanghai Conservatory of music. He has scored not only a wide range of films, TV shows and video games, but has also written many popular songs influenced by traditional Chinese culture. He is one of the most versatile and respected composers currently working in the industry, Zhiyi Chen's career spans over fifteen years. These results form an important basis for the rational design of higher-order peptide assemblies with novel properties based on unusual α-sheet secondary structures. Simulated circular dichroism spectra based on α-sheet oligomers validate the proposed α-sheet secondary structures. Molecular dynamics simulations from monomers to trimers reveal that the two heteropeptides fold into α-sheets instead of β-sheets, which readily pack into tubular architectures in oligomer simulations. Microscopic imaging, neutron scattering, and spectroscopic measurements indicate that the two heterochiral peptides form highly ordered wide nanotubes and helical ribbons with monolayer thickness, in sharp contrast to twisted nanofibrils formed by the homochiral peptide Ac-LLLLK-NH 2. In light of the strong propensity of leucine toward forming helical conformations and its high hydrophobicity, we design two short amphiphilic peptides Ac-L DLL DLK-NH 2 and Ac- DLL DLL DK-NH 2 with alternating l- and d-form amino acids. In this work, we report the design of a new peptide self-assembly strategy based on unusual α-sheet secondary structures. Unusual secondary structures hold promise as a source to develop novel supramolecular architectures with unique properties. Peptide self-assembly is a hierarchical process during which secondary structures formed in the initial stages play a critical role in determining the subsequent assembling processes and final structural ordering. ![]()
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